Table 8 |
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|
Summary of studies that examined the safety of treatment interventions for people with diabetes |
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|
Study |
Design |
Subjects |
Infection |
Organism |
Intervention |
Assessment (week) |
|
|
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|
Gupta [42] |
RCT |
Itraconazole N = 35 Sex = 16 M; 19 F Age = 57.77 (2.3) yr Terbinafine N = 35 Sex = 18 M; 17 F Age = 63.65 (1.9) yr |
DLSO |
Dermatophyte |
Ciclopirox 8% Ciclopirox 8% nail lacquer applied to nail and 5 mm surrounding skin. Daily application over the previous coat, removed after 7 days using isopropyl alcohol. Nails trimmed and debrided at each scheduled visit (8 weeks) |
48 |
|
|
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|
Brenner [43] |
Case series |
N = 49† Sex = 36 M; 13 F Age = 63.8 (12.0) yr Duration of diabetes = 8.4 (7.4) yr Duration of infection = 10.8 (15.3) yr |
DSO†† |
Not reported† |
Terbinafine 250 mg terbinafine daily 12 weeks |
48 |
|
|
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|
Farkas [46] |
Case series |
N = 89 Sex = 47 M; 42 F Age = 55.7 (11.7) yr Duration of diabetes = 10.2 (7.7) Duration of infection = 5.4 (6.0) |
DSO |
Dermatophyte (67.4%); moulds (5.6%); yeast (4.5%) |
Itraconazole pulse therapy 200 mg of oral itraconazole taken twice a day for the first week of three consecutive months Terbinafine 250 mg of oral terbinafine once daily for 12 weeks. |
48 |
|
|
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|
Sadighha [41] |
Case series |
N = 13 Sex = NR Age = NR |
DSO†† |
Dermatophyte† |
Pulse itraconazole therapy 200 mg of oral itraconazole taken twice a day for the first week of four consecutive months |
26 |
|
|
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|
† Concomitant tinea pedis was present. "DSO" = distal subungual onychomycosis; "DLSO" = distal lateral subungual onychomycosis Study 4 is excluded from the graph because efficacy was not assessed at week 48 like the rest of the studies. Sadighha [41] found itraconazole achieved cure in 7.7% (1/13) of patients with diabetes at week 26 |
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|
Matricciani et al. Journal of Foot and Ankle Research 2011 4:26 doi:10.1186/1757-1146-4-26 |
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